BRANDON SMITH

Mr. Smith has served as Prothena’s Chief Operating Officer since September 2021. He served as Chief Business Officer from 2020 through September 2021. Prior to joining Prothena, he was Chief Operating Officer at Iconic Therapeutics, Inc. from 2017 to 2020. From 2012 to 2017, Mr. Smith held senior positions at Impax Laboratories, LLC, including Senior Vice President, Corporate Development and Strategy. Mr. Smith also held several positions of increasing responsibility at Amgen Inc. between 2005 and 2012, including the head of strategy for the company’s biosimilars business unit and the head of strategy and transaction analysis supporting a variety of M&A and licensing activities. Prior to Amgen, Mr. Smith was a Project Leader at The Boston Consulting Group. Mr. Smith earned his BS in Chemical Engineering at the University of Michigan and his MBA from The University of Texas at Austin McCombs Graduate School of Business.