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“Being a patient changed my life forever,” Part Two — Amyloidosis Research Consortium founder and CEO, Isabelle Lousada, shares how the organization was born, and how it supports patients today

March 28, 2025

Earlier this month, we had the privilege of hearing firsthand from Isabelle Lousada about her journey to an AL amyloidosis diagnosis nearly 30 years ago and her successful stem cell transplant. After achieving complete remission, Isabelle founded the Amyloidosis Research Consortium (ARC) with the goal of uniting different stakeholders to improve outcomes for patients with […]

“Being a patient changed my life forever,” Part One — Shining a light on Isabelle’s story this Amyloidosis Awareness Month

March 21, 2025

At Prothena, we feel fortunate to hear from patients whose stories inspire us to continue to innovate for those who are in dire need of new treatment options. Each story fuels our commitment to keep patients and their needs at the forefront of our efforts. We are equally grateful for our relationships with advocacy organizations, […]

A transformational year: President and CEO Dr. Gene Kinney discusses what lies ahead for Prothena in 2025

March 07, 2025

Prothena recently reported fourth quarter and full year 2024 financial results, another successful year of progress in our effort to address unmet needs for the millions of patients and their loved ones that are affected by devastating, life-threatening diseases caused by protein dysregulation. With many of our clinical programs nearing significant inflection points in 2025, […]

The future of those living with rare disease, imagined by Prothenians

February 28, 2025

February 28 marks Rare Disease Day, a time to raise awareness and generate change for the 300 million people worldwide living with a rare disease, along with their families and caregivers. This year’s theme, “more than you can imagine,” inspired us at Prothena to dream beyond the ordinary. We asked a few Prothenians, “What […]

Say yes… you just might find your passion: an open letter to young women entering STEM

February 06, 2025

February 11 marks International Day of Women and Girls in Science. Last year, Donna-Lee Destouche, Head of Clinical Trial Management at Prothena, shared advice on inspiring the next generation of female leaders in STEM. Today, we’re honored to hear from Chi Johnson, Associate Director of Facilities and Environment Health & Safety (EH&S) at Prothena. Chi’s […]

Advancing Alzheimer’s Disease Research Through Diversity in Clinical Trials

January 05, 2025

The prevalence and impact of Alzheimer’s disease varies by sex, race and ethnicity. In fact, according to the Alzheimer’s Association, nearly two-thirds of people living with Alzheimer’s disease are women. Black Americans are nearly twice as likely as White Americans to develop Alzheimer’s disease or another dementia, and Hispanic Americans are 1.5 times as likely. […]

National Family Caregivers Month: Shining a Light on Jessica’s Story

November 14, 2024

This summer we shared the powerful story of LuPita, currently living with dementia. Today we are honored to introduce Jessica, LuPita’s daughter and care partner, in honor of November marking National Family Caregivers Month. Hear firsthand from Jessica on how she decided to take on the vital role, the importance of taking care of oneself […]

Meet our new CDO: Chad J. Swanson, Ph.D., Chief Development Officer answers questions about his career and the Prothena team

October 31, 2024

This month, we’re excited to hear from the newest member of our leadership team at Prothena! In September, Chad Swanson was appointed as Prothena’s new Chief Development Officer. A neuropharmacologist with over 20 years industry experience, Chad joined Prothena as Senior Vice President and Head of Clinical Development in January 2023. In his new role, […]

World Amyloidosis Day: Shining a Light on Steve’s Story

October 24, 2024

Tomorrow marks World Amyloidosis Day, and we at Prothena are proud to join the Amyloidosis Alliance to help raise awareness of amyloidosis, a complex disease often misunderstood and misdiagnosed by medical professionals and unheard of by the general public. In the below video, Steve, living with AL amyloidosis, talks about the difficult and long journey […]

It’s not a sprint… Christie Nie M.D. MSc. Vice President, Global Clinical Development answers questions about her career and Prothena’s clinical development team

October 14, 2024

From running marathons to developing potential breakthrough treatments, for Christie it’s all about perseverance At Prothena, our mission is to bring life-changing therapies to patients battling neurodegenerative and rare peripheral amyloid diseases. Our clinical development efforts play a vital role in moving these therapies from early research to potential treatments that could improve the lives […]

World Alzheimer’s Day: Shining a Light on Phil’s Story

September 06, 2024

Saturday, on World Alzheimer’s Day, we at Prothena joined Alzheimer’s Disease International to raise awareness of Alzheimer’s disease and challenge the stigma of this disease and other dementias. We recently shared the story of LuPita, currently living with dementia. Today, we are honored to help Phil tell his story. In another powerful tale, Phil underscores […]

Alzheimer’s Disease International CEO Paola Barbarino answers questions about the organization’s work in dementia and Alzheimer’s disease

August 26, 2024

Alzheimer’s disease is a devastating form of dementia that causes memory, thinking and behavior problems. It is believed two different proteins – Aβ (amyloid beta) and tau – are the primary contributors to its pathology. Misfolded Aβ builds up to form plaques between nerve cells in the brain. Tangles of twisted tau fibrils spread from […]

On putting the puzzle pieces together: the long journey to an AL amyloidosis diagnosis

August 05, 2024

Earlier this year, we heard advice for people living with AL amyloidosis from an AL amyloidosis patient herself, Linda. Today, we continue to elevate firsthand perspectives of people directly impacted by this rare disease. Hear from Donna, a wife and mother, and caregiver to her husband Mike who is living with AL amyloidosis. She describes […]

Carol Karp, Chief Regulatory Officer, answers questions about her career and Prothena’s regulatory team

July 25, 2024

Prothena is committed to developing novel and transformative medicines to create a better future for patients with neurodegenerative and rare peripheral amyloid diseases, which affect millions of people and their families worldwide. Before any treatment is made available to patients in the U.S., it must go through a rigorous set of clinical and nonclinical testing […]

The Longest Day: Shining a Light on LuPita’s Story

June 18, 2024

Today marks The Longest Day. It’s the summer solstice and the day with the most sunlight all year long. Also today, we stand with the Alzheimer’s community to fight the darkness of Alzheimer’s disease and all other dementias. There has been remarkable progress in the treatment of Alzheimer’s disease in the past few years, […]

A novel mechanism of action to address unmet needs in AL amyloidosis

May 29, 2024

AL amyloidosis, a rare, progressive and often fatal disease, occurs when a type of immune cell, called plasma cells, produce high levels of an abnormal protein called light chain that misfolds and clumps together to form aggregated amyloid which the body cannot break down. Clumped together, the amyloid can travel through blood vessels, damaging cells […]

Yvonne Tchrakian, Corporate Secretary and Legal Counsel at Prothena, shares her perspective on supporting women, including mothers, in the workplace

May 13, 2024

Earlier this year we heard from Donna-Lee Destouche who shared advice on encouraging the next generation of female leaders in STEM. In her interview, she notes, “if we have some support to be ambitious in our career, and perhaps not lose a step because you’ve decided you wanted to start a family, we may have […]

Understanding Proteins — their role in life, and in some of the most challenging diseases we face today

April 17, 2024

Proteins are essential for life. Every cell in our body makes protein every day. And for those proteins to work correctly, they need to fold in a certain three-dimensional shape and space. Systems in our cells recognize misshapen proteins and try to fix them. If they can’t help fold them into the correct shape, the […]

On advice: Linda shares wisdom for other AL amyloidosis patients

March 21, 2024

March is Amyloidosis Awareness Month, and at Prothena we believe it’s important to shine light on firsthand perspectives from people directly impacted by the disease. In this video, Linda offers advice to those affected by AL amyloidosis. Whether advice for others impacted by the disease, the journey to diagnosis, or working together with a care […]

Amyloidosis Foundation President Mary O’Donnell answers questions about the organization’s work in amyloidosis

March 21, 2024

AL amyloidosis is a rare, progressive and life-threatening disease that leads to the production and aggregation of misfolded toxic light chain proteins. These aggregates cause problems in the body’s circulation, depositing in the heart and kidney, leading to damage and organ failure. Patients often present with a wide range of general symptoms that are common […]